2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0215S7
    L-Phenylalanine-3-13C
    		Antagonist 99.56%
    L-Phenylalanine-3-13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-3-<sup>13</sup>C
  • HY-108974
    Drotaverine hydrochloride
    		Antagonist 99.65%
    Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine hydrochloride
  • HY-B0405S
    Bupivacaine-d9
    		99.04%
    Bupivacaine-d99 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
    Bupivacaine-d<sub>9</sub>
  • HY-B1376
    Methsuximide
    		99.68%
    Methsuximide is an anticonvulsant agent. Methsuximide is effective in petit mal, psychomotor and focal motor attacks.
    Methsuximide
  • HY-B0282AS1
    Acetylcholine-d4 bromide
    		98.0%
    Acetylcholine-d4 (bromide) is the deuterium labeled Acetylcholine bromide.
    Acetylcholine-d<sub>4</sub> bromide
  • HY-B0166S6
    L-Ascorbic acid-d2
    		99.90%
    L-Ascorbic acid-d2 is the deuterium labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a colla
    L-Ascorbic acid-d<sub>2</sub>
  • HY-B0282AS
    Acetylcholine-d9 bromide
    		98.86%
    Acetylcholine-d9 (bromide) is the deuterium labeled Acetylcholine bromide.
    Acetylcholine-d<sub>9</sub> bromide
  • HY-N7395A
    Cyclic ADP-​ribose ammonium
    		Activator 99.9%
    Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.
    Cyclic ADP-​ribose ammonium
  • HY-P3386A
    Selcopintide acetate
    		99.63%
    Selcopintide (Cpne7-DP) acetate consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide acetate highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide acetate promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin.
    Selcopintide acetate
  • HY-19664
    Pranidipine
    		Inhibitor 99.52%
    Pranidipine (OPC-13340) is a potent, long acting 1,4-dihydropyridine calcium channel blocker with antihypertensive activity.
    Pranidipine
  • HY-18600
    Azimilide
    		Inhibitor 99.01%
    Azimilide (NE-10064) is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ)) and IKr (IC50 = 1 μM (4 mM [K⁺])). Azimilide blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide can be used for the study of atrial fibrillation and ventricular fibrillation.
    Azimilide
  • HY-P0149
    Katacalcin
    		99.56%
    Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide.
    Katacalcin
  • HY-108608
    o-3M3FBS
    		99.88%
    o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner.
    o-3M3FBS
  • HY-105117
    Fantofarone
    		Inhibitor 99.91%
    Fantofarone is a highly potent Calcium Channel antagonist.
    Fantofarone
  • HY-16125
    Carboxyamidotriazole Orotate
    		Inhibitor 99.74%
    Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.
    Carboxyamidotriazole Orotate
  • HY-N7503
    Psoralenoside
    		Inhibitor 99.84%
    Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
    Psoralenoside
  • HY-101237
    DHBP dibromide
    		99.17%
    DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
    DHBP dibromide
  • HY-B0480
    Brompheniramine maleate
    		Inhibitor 99.78%
    Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.
    Brompheniramine maleate
  • HY-162345
    CK-963
    		99.67%
    CK-963 is an activator for cardiac troponin (cTnC) with Ki of 11.5 μM. CK-963 exhibits activity in enhancing cardiac contractility in Sprague-Dawley rats.
    CK-963
  • HY-100928
    YS 035 hydrochloride
    		Antagonist 99.15%
    YS 035 hydrochloride is a Ca2+ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca2+ uptake by muscle cells and inhibits Na+/Ca2+ exchange (Ki=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca2+ transport.
    YS 035 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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